Gibco CTS OpTmizer Pro SFM is a novel serum-free medium (SFM) developed for the growth and expansion of human T lymphocytes (e.g., CD4+, CD8+, polyclonal, or antigen-specific) used in allogeneic cell therapies. This medium improves central memory phenotype and cell growth by shifting the cell’s metabolism. The result is a larger population of central memory cells in a shorter period of time.
CTS OpTmizer Pro SFM consists of CTS OpTmizer Pro Basal Medium and CTS OpTmizer Supplement, which are mixed together prior to use.
CTS OpTmizer Pro SFM in 5 L and 10 L bag format is compatible with closed-system processing for media preparation and integration to standard cell therapy equipment, including CTS devices (Xenon, Rotea, and DynaCellect).
Benefits of CTS OpTmizer Pro SFM include:
• Supplement component now in bag format to allow for closed mixing with basal medium
• Reduces the number of open steps in your process, thus reducing contamination risks
• Easy integration with cell therapy equipment, including CTS Xenon, Rotea, and DynaCellect
• Maintains central memory T cells further into expansion and is well suited for longer workflows (>15 days)
• Offers >90% (average) T-cell fold-expansion (from healthy donors) compared to CTS OpTmizer medium
• Modest increases in central memory cells at early stage in expansion protocol result in larger cell yields at harvest
• Helps achieve the same number of cells in a shorter duration
• Ideally suited to the production of allogeneic therapies
Features include:
• Flexible pack sizes in Aegis5-14 film: basal medium in 5 L and 10 L bags
• Weldable C-Flex and PVC lines
• Supports allogeneic T-cell processes through all stages of development and manufacturing
• Supports T-cell activation using Dynabeads magnetic beads, soluble antibodies, and stimulatory antibody-presenting cell protocols
Increased efficiency and consistence performance
CTS OpTmizer Pro SFM, no phenol red, is serum-free and xeno-free and supports high density cultures in static cultures. It displays consistent performance in the support of T-cell expansion with better central memory phenotype in a shorter time.
Enhanced expansion
CTS OpTmizer Pro SFM, no phenol red, increases the number of central memory cells at an early stage in the expansion process and maintains T-cell functionality.
Enhanced design and compatibility
The supplement component is now in a bag with a weldable PVC line, allowing for closed-system mixing with the CTS OpTmizer Pro basal medium bag. This feature, along with larger 5 L and 10 L basal medium sizes, addresses manufacturers’ need for scale, efficiency, and contamination risk mitigation.
Use of Thermo Scientific Aegis5-14 Film allows compatibility with closed systems. This film is a five-layer cast film produced in a cGMP facility. The outer layer is a polyester elastomer coextruded with an ethyl vinyl alcohol (EVOH) barrier layer and an ultra-low density polyethylene product contact layer. Aegis5-14 Film is manufactured using no animal derived components.
Simplify your transition into clinical research
The Gibco Cell Therapy Systems (CTS) brａnd offers a broad array of products for use in cell therapy applications, including media, reagents, growth factors, enzymes, cell selection/expansion reagents, and devices. CTS products deliver:
• Reduced burden in qualifying reagents
• Appropriate certificates of analysis and origin available
• Convenient access to our Drug Master File (DMF)
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