DBCO-PEG-MAL,二苯基環(huán)辛炔PEG馬來酰亞胺,（Dibenzocyclooctyne）PEG
DBCO-PEG|羧基PEG|巰基PEG|疊氮PEG|八臂PEG|四臂PEG|活性酯PEG|葉酸PEG|生物素PEG|馬來酰亞胺PEG|熒光素PEG|羅丹明PEG|丙烯酸酯PEG|磷脂PEG|琥珀酰亞胺PEG|炔基PEG|羥基PEG|葉酸PEG

DBCO-PEG-MAL,二苯基環(huán)辛炔PEG馬來酰亞胺,(Dibenzocyclooctyne)PEG

 

結構式：

 

基本信息：

中文名：二苯基環(huán)辛炔PEG馬來酰亞胺，二苯基環(huán)辛炔聚乙二醇馬來酰亞胺

英文名：DBCO-PEG-MAL, Dibenzocyclooctyne-PEG-Maleimide

分子量：400、600、1K、2K、3.4K、4K、5K、10K

應用簡介：

Maleimide PEG DBCO (dibenzocycolctyne) is DBCO PEG derivatives that can go Click Chemistry reaction without a need of any metal catalysts. The strain-promoted 1,3-dipolar cycloaddition of cyclooctynes and azides, also termed as the Cu-free click reaction, is a bioorthogonal reaction that enables the conjugation of two molecules in aueous solution. DBCO PEG derivatives possess fast kinetics and stability in aueous buffer. DBCO reagents can be used to label azide-modified biomolecules spontaneous without the need for toxic Cu catalysts. Meanwhile, maleimide group can react with sulfhydryl (Thoil) groups at pH 6.5-7.5 easily. PEGylation can increase solubility and stability and reduce immunogenicity of peptides and proteins. It can also suppress the non-specific binding of charged molecules to the modified surfaces.

Copper-free Click Reaction Procedures:

Prepare the azide-containing reagents in reaction buffer.

Add DBCO reagents to azide containing reagents. Add 1 mol euivalent of limiting reagent to 1.5~3.0 mol euivalents of abundance reagent.

Incubate the reaction at room temperature for 2~4 hours or 2~12 hours at 4℃.

Purify conjugates either by dialysis or size-exclusion chromatograph.

物理性質：

狀態(tài)：淡黃色到黃色固體，或者半固體，取決于分子量。

溶解性：溶于DMSO,DMF等溶劑。

保持條件：-20℃長期保存，避光，干燥。

注意事項：取用一定要干燥，避免頻繁的溶解和凍干。

反應性：DBCO于含有N3基團的反應。MAL可以和SH。

 

DBCO（Dibenzocyclooctyne）PEGs其他產品:

DBCO-PEG-MAL,MW:2000  二苯基環(huán)辛炔PEG馬來酰亞胺

DBCO-PEG-MAL,MW:3400  二苯基環(huán)辛炔PEG馬來酰亞胺

DBCO-PEG-MAL,MW:5000  二苯基環(huán)辛炔PEG馬來酰亞胺

DBCO-PEG-MAL,MW:10000 二苯基環(huán)辛炔PEG馬來酰亞胺

 

DBCO-PEG-NH2,MW:2000  二苯基環(huán)辛炔PEG氨基

DBCO-PEG-NH2,MW:3400  二苯基環(huán)辛炔PEG氨基

DBCO-PEG-NH2,MW:5000  二苯基環(huán)辛炔PEG氨基

DBCO-PEG-NH2,MW:10000 二苯基環(huán)辛炔PEG氨基

 

mPEG-DBCO,MW:1000   甲氧基PEG二苯基環(huán)辛炔

mPEG-DBCO,MW:2000   甲氧基PEG二苯基環(huán)辛炔

mPEG-DBCO,MW:3400   甲氧基PEG二苯基環(huán)辛炔

mPEG-DBCO,MW:5000   甲氧基PEG二苯基環(huán)辛炔

mPEG-DBCO,MW:10000  甲氧基PEG二苯基環(huán)辛炔

mPEG-DBCO,MW:20000  甲氧基PEG二苯基環(huán)辛炔              

 

DBCO-PEG-NHS,MW:2000 二苯基環(huán)辛炔PEG活性酯

DBCO-PEG-NHS,MW:3400 二苯基環(huán)辛炔PEG活性酯

DBCO-PEG-NHS,MW:5000 二苯基環(huán)辛炔PEG活性酯

DBCO-PEG-NHS,MW:10000二苯基環(huán)辛炔PEG活性酯

 

DBCO-PEG-Biotin,MW:2000  二苯基環(huán)辛炔PEG生物素

DBCO-PEG-Biotin,MW:3400  二苯基環(huán)辛炔PEG生物素

DBCO-PEG-Biotin,MW:5000  二苯基環(huán)辛炔PEG生物素

DBCO-PEG-Biotin,MW:10000 二苯基環(huán)辛炔PEG生物素

 

DBCO-PEG-COOH,MW:2000 二苯基環(huán)辛炔PEG羧酸

DBCO-PEG-COOH,MW:3400 二苯基環(huán)辛炔PEG羧酸

DBCO-PEG-COOH,MW:5000 二苯基環(huán)辛炔PEG羧酸

DBCO-PEG-COOH,MW:10000二苯基環(huán)辛炔PEG羧酸

 

DBCO-PEG-Folate,MW:2000  二苯基環(huán)辛炔PEG葉酸

DBCO-PEG-Folate,MW:3400  二苯基環(huán)辛炔PEG葉酸

DBCO-PEG-Folate,MW:5000  二苯基環(huán)辛炔PEG葉酸

 

DBCO-PEG-Cholesterol,MW:2000 二苯基環(huán)辛炔PEG膽固醇

DBCO-PEG-Cholesterol,MW:3400 二苯基環(huán)辛炔PEG膽固醇

DBCO-PEG-Cholesterol,MW:5000 二苯基環(huán)辛炔PEG膽固醇

 

DBCO-PEG-Glucose,MW:2000  二苯基環(huán)辛炔PEG葡萄糖

DBCO-PEG-Glucose,MW:5000  二苯基環(huán)辛炔PEG葡萄糖

 

DBCO-PEG-Silane,MW:2000 二苯基環(huán)辛炔PEG硅烷

DBCO-PEG-Silane,MW:3400 二苯基環(huán)辛炔PEG硅烷

DBCO-PEG-Silane,MW:5000 二苯基環(huán)辛炔PEG硅烷

 

DBCO-PEG-MAL,二苯基環(huán)辛炔PEG馬來酰亞胺,(Dibenzocyclooctyne)PEG

Structure	M.W.	Purity
DBCO-acid & DBCO-PEG acid
DBCO-acid		98%
DBCO-C6-acid		96%
DBCO-PEG4-acid		98%
DBCO-PEG5-acid		95%
DBCO-PEG13-acid		98%
DBCO-CONH-PEG4-acid		95%
DBCO-NHS ester
DBCO-NHS		97%
DBCO-C6-NHS ester		95%
DBCO-Sulfo-NHS ester		97%
DBCO-PEG-NHS ester
DBCO-PEG4-NHS ester		96%
DBCO-PEG5-NHS ester		95%
DBCO-PEG13-NHS ester		90%
DBCO-CONH-PEG4-NHS ester		97%
PC DBCO-PEG4-NHS ester		95%
DBCO-PEG-PFP ester
DBCO-PEG4-PFP ester		95%
DBCO-PEG-Alcohol
DBCO-PEG4-alcohol		95%
DBCO-amine & DBCO-PEG-amine
DBCO-amine		96%
Sulfo DBCO-amine		95%
DBCO-PEG4-amine		98%
Sulfo DBCO-PEG4-amine		95%
DBCO-PEG-NH-Boc
DBCO-PEG4-NH-Boc		97%
BDP FL DBCO
BDP FL DBCO		95%
Fluorescein-DBCO
Fluorescein-DBCO		95%
Carboxyrhodamine-PEG-DBCO
Carboxyrhodamine 110PEG4-DBCO		95%
Sulforhodamine-PEG-DBCO
Sulforhodamine-PEG4-DBCO		95%
TAMRA-PEG-DBCO
TAMRA-PEG4-DBCO		95%
DBCO-Biotin & DBCO-PEG-Biotin
DBCO-PEG4-biotin		95%
DBCO-Sulfo-Link-biotin		95%
DBCO-PEG4-Desthiobiotin		95%
DBCO-PEG-DBCO
DBCO-PEG4-DBCO		95%
DBCO-PEG5-DBCO		95%
DBCO-Maleimide & DBCO-PEG-Maleimide
DBCO-Maleimide		95%
Sulfo DBCO-Maleimide		95%
DBCO-PEG4-Maleimide		95%
Sulfo DBCO-PEG4-Maleimide		90%
TCO-PEG-DBCO
TCO-PEG12-DBCO		95%
Tetrazine-PEG-DBCO
Methyltetrazine-PEG12-DBCO		95%
Methyltetrazine-DBCO		95%
DBCO-mPEG
DBCO-mPEG 5KDa
DBCO-mPEG 10KDa
DBCO-mPEG 20KDa

DBCO-PEG-MAL,二苯基環(huán)辛炔PEG馬來酰亞胺,(Dibenzocyclooctyne)PEG