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Recombinant Human BD-2 貨號(hào):300-49 細(xì)胞因子

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Recombinant Human BD-2 貨號(hào):300-49 細(xì)胞因子
細(xì)胞因子(cytokine,CK)是一類(lèi)能在細(xì)胞間傳遞信息、具有免疫調(diào)節(jié)和效應(yīng)功能的蛋白質(zhì)或小分子多肽。
作用特點(diǎn)：多效性、重疊性、協(xié)同性、拮抗性和雙重性。

詳細(xì)介紹

Recombinant Human BD-2 貨號(hào):300-49 細(xì)胞因子

 

細(xì)胞因子受體的結(jié)構(gòu)和分類(lèi):根據(jù)細(xì)胞因子受體cDNA序列以及受體胞膜外區(qū)氨基酸序列的同源性和結(jié)構(gòu)征，可將細(xì)胞因子受體主要分為四種類(lèi)型：免疫球蛋白超家族（IGSF）、造血細(xì)胞因子受體超家族、神經(jīng)生長(zhǎng)因子受體超家族和趨化因子受體。

 

Catalog Number:
300-49
Synonyms:
Skin-antimicrobial peptide 1, SAP1, DEFB2, DEFB4A
Description:
Defensins （alpha and beta） are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and in some cases, a propeptide sequence. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Recombinant human BD-2 is a 4.3 kDa protein containing 41 amino acid residues.
AA Sequence:
GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to chemoattract immature human dendritic cells using a concentration of 10.0-100.0 ng/ml.
 
 
 
 
Cross Reactivity:
Bacteria, Rat, Virus, Human
 
 
Country of Origin:
USA


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