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Recombinant Human TNF-a 貨號(hào):300-01A 細(xì)胞因子

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Recombinant Human TNF-a 貨號(hào):300-01A 細(xì)胞因子
細(xì)胞因子(cytokine,CK)是一類能在細(xì)胞間傳遞信息、具有免疫調(diào)節(jié)和效應(yīng)功能的蛋白質(zhì)或小分子多肽。
作用特點(diǎn):多效性、重疊性、協(xié)同性、拮抗性和雙重性。

詳細(xì)介紹

Recombinant Human TNF-a 貨號(hào):300-01A 細(xì)胞因子 

 

細(xì)胞因子受體的結(jié)構(gòu)和分類:根據(jù)細(xì)胞因子受體cDNA序列以及受體胞膜外區(qū)氨基酸序列的同源性和結(jié)構(gòu)征,可將細(xì)胞因子受體主要分為四種類型:免疫球蛋白超家族(IGSF)、造血細(xì)胞因子受體超家族、神經(jīng)生長(zhǎng)因子受體超家族和趨化因子受體。

 

Catalog Number:
300-01A
Synonyms:
Tumor Necrosis Factor, TNFSF2, Cachectin, Differentiation-inducing factor (DIF), Necrosin, Cytotoxin
Description:
TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant human TNF-α is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.
AA Sequence:
VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIAL
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
 
 
 
 
Cross Reactivity:
Cow, Monkey, Mouse, Rat, Sheep, Human, Bacteria, Human + Rat, Pig, Dog
Research Interests:
AIDS /  HIV AIDS / HIV Angiogenesis/ Cardiovascular Angiogenesis/ Cardiovascular
Apoptosis Apoptosis Cancer Cancer
Diabetes /  Weight Regulation Diabetes / Weight Regulation Immune System Immune System
Inflammation Inflammation Neurobiology Neurobiology
Stem Cells & Differentiation Stem Cells & Differentiation TNF Superfamily TNF Superfamily
Allergy Allergy Transplantation Transplantation
 
 
Country of Origin:
USA


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